
信州大学 農学部 生命・食品科学コース
【大学院 総合理工学研究科 食品生命科学分野】
Kawahara Laboratory 河原研究室
機能性畜産物製造学研究室
信州味噌由来乳酸菌の機能性に着目した発酵長寿プロジェクト
FFIジャーナル, 225(3): 230-237, 2020
河原岳志
皮膚角化細胞由来のケモカイン(TARC)抑制によるアトピー性皮膚炎の軽減
アレルギーの臨床, 509(38): 46-50, 2018
河原岳志
Effect of topical application of an extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice
Fragrance Journal Korea, 6: 99-103, 2017
Kawahara T., Hamauzu Y, Inoue T.
マルメロ熱水抽出物の塗布によるNC/Nga系マウスにおける皮膚炎抑制効果
フレグランスジャーナル, 5: 58-61, 2017
河原岳志、濵渦康範、井ノ上利文
ダチョウ肉はヘルシーミート
みすずかる信濃の健康志向食品: 187-205, 2003
信州大学農学部 機能性食料開発学専攻
In vitro immunization of human peripheral blood lymphocytes with cholera toxin B subunit
New Developments and New Applications in Animal Cell Technology, 9(4): 617-623, 2002
Ichikawa, A., Katakura, Y., Kawahara, T., Hashizume, S., Shirahata, S.
❖ 著書
Inhibitory effect of cardamom seed hot-water extract on human influenza A virus infection
Phytomedicine Plus, 6(3), 100996, 2026
Shuvo A.A.S., Maekawa Y., Kassai M., Kawahara T.
Type I interferon-enhancing effect of cardamom seed extract via intracellular nucleic acid sensor regulation
Foods, 14(15), 2744-2744, 2025
Shuvo A.A.S., Kassai M., Kawahara T.
Inhibitory effects of a hot-water extract of cumin fruit on influenza A virus infection
PLOS One, 20(6), e0326423, 2025
Shuvo A.A.S., Maekawa Y., Kassai M., Kawahara T.
Heat-killed Lactiplantibacillus plantarum Shinshu N-07 exerts antiobesity effects in western diet-induced obese mice
Journal of Applied Microbiology, 135(5), 2024
Tanaka Y., Inaba C., Sawa T., Endo K., Saiki T., Haga H., Niitsuma F., Kawahara T., Watanabe J., Tanaka S.
クロモジ熱水抽出物の抗インフルエンザウイルス活性成分の検討
薬理と治療, 51(2), 193-201, 2023
河原岳志, 芦部文一朗, 松見 繁
クロモジ熱水抽出物のコロナウイルスOC43に対する感染抑制作用
薬理と治療, 50(2): 195-201, 2022
河原岳志, 芦部文一朗, 松見 繁
Lactobacillus crispatus strain KT-11 S-layer protein inhibits rotavirus infection
Frontiers in Microbiology, 13: 783879, 2022
Kawahara, T., Shimizu, I., Tanaka, Y., Tobita, K., Tomokiyo, M., Watanabe, I.
Anti-degranulatory and bile acid-binding activity of extracts prepared from fruits and agro-industrial by-products
Food Bioscience, 43: 101244, 2021
Hamauzu. Y., Kawahara. T.
Inhibitory effect of strawberry geranium (Saxifraga stolonifera) on Toll-like receptor 2-mediated inflammatory response in human skin keratinocytes
Journal of Ethnopharmacology, 275: 114039, 2021
Kawahara, T., Ito, A., Kiso. A., Kuwamoto. F.
Metabolomic evaluation of different starter culture effects on water-soluble and volatile compound profiles in nozawana pickle fermentation
Food Chemistry: Molecular Sciences, 2(30): 100019, 2021
Tomita, S., Watanabe, J., Kuribayashi, T., Tanaka, S., Kawahara, T.
クロモジ熱水抽出物のインフルエンザウイルス感染抑制メカニズムの検討
薬理と治療, 48(8): 1357-1371, 2020
河原岳志, 芦部文一朗, 松見 繁, 丸山徹也
Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice
Beneficial Microbes, 11(7): 655-667, 2020
Yin, T., Bayanjargal, S., Fang, B., Inaba, C., Mutoh, M., Kawahara, T., Tanaka, S., Watanabe, J.
Suppressive effects of hot-water extract of Magnolia obovata on Clostridium perfringens enterotoxin-induced cytotoxicity in human intestinal Caco-2 cells
Planta Medica, 86(3): 198-204, 2020
Kawahara, T., Fujii, K., Nakajima, K., Fujii, R., Inagaki, S., Yasui, H.
クロモジ熱水抽出物の持続的なインフルエンザウイルス増殖抑制効果
薬理と治療, 47(8): 1197-1204, 2019
河原岳志, 芦部文一朗, 松見 繁, 丸山徹也
Characterization of microbiota that influence immunomodulatory effects of fermented Brassica rapa L.
Microbes and Environments, 34(2): 206-214, 2019
Sandagdorj, B., Hamajima, C., Kawahara, T., Watanabe, J., Tanaka, S.
Effect of Lactobacillus strains on thymus and activation-regulated chemokine expression in keratinocytes and the development of atopic dermatitis-like symptoms
Beneficial Microbes, 9(4): 643-652, 2018
Kawahara, T., Hanzawa, N., Sugiyama, M.
Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice
BMC Complementary and Alternative Medicine, 17(1): 80, 2017
Kawahara, T., Tsutsui, K., Nakanishi, E., Inoue, T., Hamauzu, Y.
Effect of oral administration of the IgE-suppressive wild yeast strain Saccharomyces paradoxus P01 on the development of atopic dermatitis-like symptoms in NC/Nga mice
Food Science and Technology Research, 21(2): 223-230, 2015
Kawahara, T., Nakayama, D., Tanaka, K., Yasui H.
Inhibitory effect of a hot-water extract of Japanese big-leaf magnolia (Magnolia obovata) on rotavirus-induced diarrhea
Evidence-Based Complementary and Alternative Medicine, 2014:365831, 2014
Kawahara, T., Tomono, T., Hamauzu, Y., Tanaka, K., Yasui, H.
Suppressive effect of wild Saccharomyces cerevisiae and Saccharomyces paradoxus strains on IgE production of mouse spleen cells
Food Science and Technology Research, 19(6): 1019-1027, 2013
Kawahara, T., Nakayama, D., Toda, K., Inagaki, S., Tanaka, K., Yasui, H.
Establishment and characterization of mouse bone marrow-derived mast cell hybridomas
Experimental Cell Research, 318(18): 2385-2396, 2012
Kawahara, T.
Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells
Cytotechnology, 63(2): 143-152, 2011
Kawahara, T., Iizuka, T.
Inhibitory effect of fermented grape pomace on degranulation in RBL-2H3 cells and an analysis of its active ingredient
Food Science and Technology Research, 17(3): 241-250, 2011
Kondo K., Nakamura K., Hamauzu Y., Kawahara T., Sansawa, H., Suzuki, M., Yasui, H.
Characterization of the bacteriocinogenic lactic acid bacteria Lactobacillus curvatus strain Y108 isolated from Nozawana-zuke pickles
Food Science and Technology Research, 16(3): 253-262, 2010
Kawahara, T., Iida, A., Toyama, Y., Fukuda, K.
Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells
Animal Science Journal, 81(6): 714-721, 2010
Kawahara, T.
Anti-allergic effect of a hot-water extract of quince (Cydonia oblonga)
Bioscience, Biotechnology, and Biochemistry, 73(8): 1773-1778 2009
Shinomiya, H., Hamauzu, Y., Kawahara, T.
Inhibitory effect of electrolyzed reduced water on tumor angiogenesis
Biological & Pharmaceutical Bulletin, 31(1): 19-26, 2008
Ye, J., Li, Y., Hamasaki, T., Nakamichi, N., Komatsu, T., Kashiwagi, T., Teruya, K., Nishikawa, R., Kawahara, T., Osada, K., Toh, K., Abe, M., Tian, H., Kabayama, S., Otsubo, K., Morisawa, S., Katakura. Y., Shirahata, S.
Catalyser-21™, a mineral water derived from leaf soil, inhibits tumor cell invasion and angiogenesis
Cytotechnology, 55(2-3): 61-70, 2007
Ye, J., Li, Y., Hamasaki, T., Nakamichi, N., Kawahara, T., Osada, K., Teruya, K., Kato, Y., Toh, K., Abe, M., Katakura, Y., Noguchi, K., Shirahata, S.
Oral ingestion of phosphorylated dextrin stimulates antibody responses in mice
Journal of Nutritional Science and Vitaminology, 53(4): 354-357, 2007
Otani, H. Morimoto, T., Kawahara, T.
Stimulatory effect of lactic acid bacteria from commercially available pickle "Nozawana-zuke" on cytokine expressions of mouse spleen cells
Bioscience, Biotechnology, and Biochemistry, 70(2): 411-417, 2006
Kawahara, T., Otani, H.
Cow's IgG1 and its proteolytic digests stimulate immunoglobulin formation in mouse spleen cell culture
Milchwissenschaft, 62(1): 9-12, 2006
Mizutani, A., Ohnuki, H., Kawahara, T., Otani, H.
Bovine β-casein (1-28), a casein phosphopeptide, enhances proliferation and IL-6 expression of mouse CD19+cells via Toll-like receptor 4.
Journal of Agricultural Food Chemistry, 54(21): 8013-8017, 2006
Tobita K, Kawahara T, Otani H.
IL-12誘導活性を示す天然葉緑土由来ミネラル水中の複合糖質の構造解析
分析化学, 54(5): 391-397, 2005
加藤祐子,太田雅也,亀井恭平,脇田久伸,河原岳志,山野 雄一郎,濱崎 武記,照屋 輝一郎,長田和浩,西川竜平,野口克己,白畑實隆
ガン特異的ヒト型モノクローナル抗体の取得
信州大学農学部紀要, 41(1-2): 7-14, 2005
河原岳志
Effect of bovine κ-caseinoglycopeptide on mitogen-induced proliferative responses of spleen cells from different strains of mice
Milchwissenschaft,60(3): 245-248, 2005
Otani, H., Horimoto, Y., Matin, M.A., Ohnuki, H., Kawahara, T.
Characterization of casein phosphopeptides from fermented milk products
Journal of Nutritional Science and Vitaminology, 51(5): 377-381, 2005
Kawahara, T., Aruga, K., Otani, H.
Stimulatory effect of a casein phosphopeptide (CPP-III) on mRNA expression of cytokines in Caco-2 cells
Bioscience, Biotechnology, and Biochemistry,68(8): 1779-1781, 2004
Kawahara, T., Otani, H.
Effect of β-casein (1-28) on proliferative responses and secretory functions of human immunocompetent cell lines
Bioscience, Biotechnology, and Biochemistry, 68(10): 2091-2095, 2004
Kawahara, T., Katayama, D., Otani, H.
Stimulatory effect of a dietary casein phosphopeptide preparation on the mucosal IgA response of mice orally ingested lipopolysaccharide from Salmonella typhimurium
Bioscience, Biotechnology, and Biochemistry, 67(4): 729-735, 2003
Otani, H., Nakano, K., Kawahara, T.
Protective mechanism of reduced water against alloxan-induced pancreatic β-cell damage; Scavenging effect against reactive oxygen species
Cytotechnology, 40(4): 139-149, 2002
Y.P. Li., Nishimura, T., Teruya, K., Maki, T., Komatsu, T., Hamasaki, T., Kashiwagi, T., Kabayama, S., Shim, S.-Y., Katakura, Y., Osada, K., Kawahara, T., Otsubo, K., Morisawa, S. Ishii, Y., Gadek, Z., Shirahata S.
Role of tachylectins in host defense of the Japanese horseshoe crab Tachypleus tridentatus
Advances in Experimental Medicine and Biology, 484: 195-202, 2001
Kawabata, S., H. G. Beisel., Huber, R., Bode, W., Gokudan, S., Muta, T., Tsuda, R., Koori, K., Kawahara, T., Seki, N., Mizunoe, Y., Wai, S. N., Iwanaga, S.
Establishment of hybridomas producing cancer specific human antibodies from B cell line derived from PBL of a patient with adult T cell leukemia
Cytotechnology, 36(1-3): 171-177, 2001
Kawahara, T., Ichikawa, A., Katakura, Y., Teruya, K., Yoshida, T., Kikuchi, M., Hashizume, S., Shirahata, S.
Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen
Proceedings of the National Academy of Sciences of the U.S.A., 96(18): 10086-10091, 1999
Gokudan, S., Muta, T., Tsuda, R., Koori, K., Kawahara, T., Seki, N., Mizunoe, Y., Wai, S.N., Iwanaga, S., Kawabata, S.